Internal: Usual doses vary between 50mg and 250mg per day. For best results take a level 1/8th teaspoon Hyaluronic Acid (223mg) mixed with juice. Topical 1/4 teaspoon Hyaluronic Acid (446mg) mixed with 1 oz. of water under comfortable room temperature conditions with lower humidity, agitation by gentle rocking from top to bottom with bottle, (slow motion shaking)